Hepatotoxicity of mild analgesics.

Hepatotoxicity of non-narcotic analgesics.

The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem. Hepatotoxicity is considered a class characteristic of nonsteroid...

Clinical evaluation of mild analgesics.

1 Mild analgesics pose particular problems in evaluation because of difficulty in getting suitable patients, the frequent use of oral administration and their long-term use. 2 Despite their limitations it is possible to quantify both pain severity and pain relief using either 'pain scores' or 'visual analogues'. 3 A trained observer can add information in addition to the patient's interpretatio...

Reasons for the use of mild analgesics among English students

Mild analgesics and the accident and emergency department--cost and safety more important than potency?

A prospective controlled trial involving over 1000 patients did not reveal any difference between four drugs commonly used in accident and emergency departments for the relief of mild to moderate pain. There were no significant variations in therapeutic effect, side-effects or patient compliance. When considering the supply of analgesics which may be no more potent than those available without ...

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...